爸爸决定儿女一生- 风采杂志
Category Archives: Epigenetics
婴儿基因好坏你做主-风采杂志
Daddy beware- How paternal age affects reproduction and offspring
Daddy beware
How paternal age affects reproduction and offspring
When it comes to discussions on fertilisation and reproduction, there is often an emphasis on the mother. This includes her age, which is also known as “maternal age.” This is quite understandable, because multiple studies have been conducted on women’s health and the effects it can have on the pregnancy and baby. And the bulk of the research shows that women over 35 do have a higher risk of infertility, pregnancy complications, spontaneous abortion, congenital anomalies and perinatal complications.
But what about paternal age? How come it’s rarely discussed? Could the age of the father have an effect on reproduction and the health of the baby both in vitro and after birth? The answer is – Yes, it’s possible.
Today, however, late fatherhood has become more commonplace. In fact, in Hollywood it has become a trend, with celebs like Steve Martin, George Lucas, Jeff Goldblum and Robert DeNiro fathering children in their 60s. And it’s not just celebs that are having children later in life.
In the last decade, we’ve seen a rising number of men becoming fathers for the first time at an advanced age. This is largely due to the increase in life expectancy, the use of contraceptives, delayed marriages and so on. Arguably, there are various social advantages to having children at a later age. For example, older fathers are often more advanced in their careers and are better equipped to provide financial security to the family. But what about potential risks? Do they outweigh the advantages?
Despite this rising trend of delayed fatherhood, research on the effects of paternal age on reproduction and offspring has been lacking. However, there is a growing body of literature on the topic, and they point to several risk factors that couples must be aware of and take into consideration.
Firstly, studies have shown the negative effects of paternal age to sperm quality and testicular function. In addition to this, older men have an increased risk of male infertility, which can adversely impact reproductive and fertility outcomes, including the success rates of treatments like IVF/ICSI.
Research also indicates that children conceived by men over the age 40 might face a higher risk of miscarriage; preterm birth; birth defects such as the bone growth disorder achondroplasia; disorders like autism, schizophrenia and bipolar disorders, as well as childhood leukemia.
But why do the risks for these health conditions increase with paternal age?
Researchers believe that these health conditions might be caused by age-related genetic mutations and chromosomal abnormalities, which in turn results in genetic mutations that are then inherited by the offspring. With these facts in mind, it’s essential for couples, especially those facing fertility issues, to consider the links between advanced paternal age and the potential risks to conception and the health of their offspring.
But, if you’re a man in your 40s or older who is considering fatherhood, or are concerned about your reproductive health, don’t hesitate to speak to your doctor. It’s best to address your worries and find out more about the potential risks involved.
Kate realised that having a child with a really tall father did have its advantages.
Daddy’s Diet
Daddy’s Diet
How a fathers’ lifestyle influences the health of future generations
We all know that a woman who is trying to conceive should eat a healthier and more nutritious diet. In addition, she should abstain from drugs, alcohol and cigarettes. This is because these factors can affect her chances of becoming pregnant, as well as have a negative effect on her developing fetus should she fall pregnant. Even a woman’ level of emotional stress could influence her fertility and pregnancy success. But does the same apply to men? How does a man’s lifestyle affect conception and the health of his offspring?
Unlike women, men’s reproductive health is under-emphasised and men are largely left out of pre-conception planning. This is despite the fact that male infertility is on the rise, with lower sperm counts and damaged sperm becoming more prevalent. Now, however, new studies are beginning to show that a father’s lifestyle can impact the possibility of pregnancy, as well as the long-term health of his children.
More than genes
Though the saying goes, “It’s all in genes,” scientists have discovered there’s more to our genetic inheritance than that. Beyond our DNA code is epigenetics, which can be defined as, “a heritable layer of biochemical information associated with DNA, and transmitted via the sperm and egg.”
According to Sarah Kimmins, PhD, who holds a Canada Research Chair in Epigenetics, Reproduction and Development and is an Associate Professor at McGill University, Montreal, “We are now beginning to understand that sperm epigenome contains a lifetime memory of paternal experiences. Everything is a man’s daily lifestyle, including his environment, diet, exercise, alcohol and smoking have the potential to disrupt (or support) the setting of the sperm epigenome, which is then passed on to future generations.”
Danger of chemicals
Besides lifestyle, says Kimmins, other factors that can contribute to male infertility are “Chronic conditions like obesity, cardiovascular disease and metabolic disorders, as well as paternal age and heightened stress.” Furthermore, the researchers at McGill University also believe that, “Reduced fertility may be in part attributable to the dramatic increases in chemical production and consequent human exposure.”
Their studies show that there are now about 80,000 chemicals registered for commercial use. We are exposed to these chemicals daily, be it at work, in household products, in the environment, as well as food and cosmetics. As an alarming result, high levels of common toxicants, like bisphenol A and phthalates can now be detected in urine and blood analysis of not just adults, but children too.
While only a handful of research groups worldwide are addressing the cause and effect of lifestyle and chemical exposure to human infertility and epigenetic inheritance, it is becoming increasingly that a father’s way of life plays a vital role in determining his child’s development and health. As such, Kimmins suggests that, “Men should become more involved in pre-conception planning and young men must be educated that their choices today may influence health beyond their own.”
Dr Helena Lim 